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KMID : 0617319920020010117
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Journal of Pharmacetical Sceiences Ewha Womans University
1992 Volume.2 No. 1 p.117 ~ p.125
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One-way membrane for transdermal drug delivery systems
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Yuk, Soon Hong
Lee, Seung Jin/Okano, Teruo/Berner, Bret/Kim, Sung Wan
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Abstract
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A new polymeric membrane, designated as a ´one-way´ membrane, was designed to be permeable to ethanol with minimal flux of drug or water. A trilaminate membrane consisting of Silastic Q7-4840, methylhydrodimethydrodinethylsiloxane and cellulose acetate was designed as the one-way membrane. Membrane permeation characteristics were determined from solvent and drug diffusion experiments. The one-way membrane, which provided optimum and constant ethanol activity, may contribute a new concept in the design of transdermal delivery systems as a rate-limiting membrane.
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